1,181 research outputs found
Non-critical string pentagon equations and their solutions
We derive pentagon type relations for the 3-point boundary tachyon
correlation functions in the non-critical open string theory with generic
c_{matter} < 1 and study their solutions in the case of FZZ branes. A new
general formula for the Liouville 3-point factor is derived.Comment: 18 pages, harvmac; misprints corrected, section 3.2 extended, a new
general formula for the Liouville 3-point factor adde
On the crossing relation in the presence of defects
The OPE of local operators in the presence of defect lines is considered both
in the rational CFT and the Virasoro (Liouville) theory. The duality
transformation of the 4-point function with inserted defect operators is
explicitly computed. The two channels of the correlator reproduce the
expectation values of the Wilson and 't Hooft operators, recently discussed in
Liouville theory in relation to the AGT conjecture.Comment: TEX file with harvmac; v3: JHEP versio
Minimal model boundary flows and c=1 CFT
We consider perturbations of unitary minimal models by boundary fields.
Initially we consider the models in the limit as c -> 1 and find that the
relevant boundary fields all have simple interpretations in this limit. This
interpretation allows us to conjecture the IR limits of flows in the unitary
minimal models generated by the fields \phi_{rr} of `low' weight. We check this
conjecture using the truncated conformal space approach. In the process we find
evidence for a new series of integrable boundary flows.Comment: (latex2e, 27 pages, 17 figures
Use of Peptide Libraries for Identification and Optimization of Novel Antimicrobial Peptides.
The increasing rates of resistance among bacteria and to a lesser extent fungi have resulted in an urgent need to find new molecules that hold therapeutic promise against multidrug-resistant strains. Antimicrobial peptides have proven very effective against a variety of multidrug-resistant bacteria. Additionally, the low levels of resistance reported towards these molecules are an attractive feature for antimicrobial drug development. Here we summarise information on diverse peptide libraries used to discover or to optimize antimicrobial peptides. Chemical synthesized peptide libraries, for example split and mix method, tea bag method, multi-pin method and cellulose spot method are discussed. In addition biological peptide library screening methods are summarized, like phage display, bacterial display, mRNA-display and ribosomal display. A few examples are given for small peptide libraries, which almost exclusively follow a rational design of peptides of interest rather than a combinatorial approach
The Virtue of Defects in 4D Gauge Theories and 2D CFTs
We advance a correspondence between the topological defect operators in
Liouville and Toda conformal field theories - which we construct - and loop
operators and domain wall operators in four dimensional N=2 supersymmetric
gauge theories on S^4. Our computation of the correlation functions in
Liouville/Toda theory in the presence of topological defect operators, which
are supported on curves on the Riemann surface, yields the exact answer for the
partition function of four dimensional gauge theories in the presence of
various walls and loop operators; results which we can quantitatively
substantiate with an independent gauge theory analysis. As an interesting
outcome of this work for two dimensional conformal field theories, we prove
that topological defect operators and the Verlinde loop operators are different
descriptions of the same operators.Comment: 59 pages, latex; v2 corrections to some formula
Expression of sialyltransferases from the St3gal, St6gal and St6galnac families in mouse skeletal muscle and mouse C2C12 myotubes
In skeletal muscles, the sialic acids have a great significance for their functional maintenance and proper structural organization. Our work described the expressions of St3gal, St6gal and St6galnac sialyltransferases specific for glycoproteins in mouse skeletal muscles and murine C2C12 myotubes. Lectin histochemistry, cytochemistry and lectin blot were used to demonstrate the membrane localization and the electrophoretic profiles of α-2,3- and α-2,6-sialylated glycoproteins. The expression levels of sialyltransferases were analysed by real time RT-PCR and western blot. The enzymes St6gal2 and St6galnac1 were not expressed in skeletal muscle tissue and C2C12 myotubes. In both experimental groups, mRNAs of the St3gal family prevailed over the mRNA expressions of the St6gal and St6galnac families. The profiles of sialyltransferase expressions showed differences between the two experimental groups, illustrated by the absence of expressions of the mRNA for the St3gal6 and St6galnac3 genes in the C2C12 cell samples and by the different shares of the enzymes St3gal3 and St3gal4 in both experimental groups. The different patterns of enzyme expressions in both experimental groups corresponded with differences between their α-2,3- and α-2,6-sialylated glycoprotein profiles. These results could be a useful addendum to the knowledge concerning the glycosylation of the skeletal muscle tissue
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